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However, its inability to cross the BBB has been a significant obstacle to achieving efficacy, with clinical trials utilizing direct intracerebral infusions of GDNF to the striatum concluding with limited efficacy, in part due to the challenges with invasive brain infusions [35]

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If a patient’s expectation is that a weekly injection will produce weight loss without dietary change, the ethical move is to reset the expectation or decline the treatment — not to sell the package